CIRCULATING MUTATIONAL PORTRAIT OF CANCER: MANIFESTATION OF AGGRESSIVE CLONAL EVENTS IN BOTH EARLY AND LATE STAGES

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages

Abstract color touch 7/97 Background Solid tumors residing in tissues and organs leave footprints in circulation through circulating tumor cells (CTCs) and circulating tumor DNAs (ctDNA).Characterization of the ctDNA portraits and comparison with tumor DNA mutational portraits may reveal clinically actionable information on solid tumors that is tra

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Diagenetic evolution of key minerals and its controls on reservoir quality of Upper Ordovician Wufeng-Lower Silurian Longmaxi shale of Sichuan Basin

Based on core, thin section, scanning electron microscopy observations, X-ray diffraction analysis, as well as carbon and oxygen isotopes and energy spectrum analysis of carbonate rocks, the quartz, feldspar, pyrite, carbonate and clay minerals in shale of the Upper Ordovician Wufeng-Lower Silurian Longmaxi formations of Sichuan Basin were effectiv

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Identification of piRNA disease associations using deep learning

Piwi-interacting RNAs (piRNAs) play a pivotal role in maintaining genome integrity by repression of transposable elements, gene stability, and association with various disease progressions.Cost-efficient computational methods for the identification of piRNA disease associations promote the efficacy of disease-specific drug development.In this regar

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